The 31st IFSCC
2020 Yokohama


Research and development-oriented chemical manufacturing company that develops cosmetic raw materials

With development, evaluation and surveying being the cornerstones of our research and development system, SEIWA KASEI CO., LTD. is a research and development - oriented company taking on the challenge of developing new materials based on the solid evidence of our original research technologies.
Since its establishment in 1958, we have presented the results of its research at large-scale conferences of cosmetics and personal care scientific societies. Also we actively carry out patent applications for our products to let the public know and understand the innovative research technologies borne out of SEIWA KASEI’s development of original materials.
Number of Japanese patent applications: 304 applications
Number of International patent applications: 78 applications


Established its status as innovative developer in cosmetic industry with over 100 original ingredients

SEIWA KASEI CO., LTD. which is widely known as a well-established manufacturer, began in the 1960s with its development of hydrolyzed collagen (collagen peptide) as raw material for cosmetics. After that, we have since evolved and expanded at a rapid rate alongside the development of applied technologies.
We have been aiming to develop raw materials with biochemical functions in new research fields and have started to develop amino acid derivatives and vitamin C derivatives since the early 2000s. Our company has since then created unique and functional raw materials. SEIWA KASEI CO., LTD. is never satisfied with the existing state and will constantly keep developing new raw materials for cosmetics that are high quality, multifunctional and original.

Research and Development

Delivers “SEIWA-quality” all over the world

We expands sales network in corporation with local distributor and export our products to the world. With the delivery of high-quality service as our watchword, SEIWA SUPPLY CO., LTD. has established a system wherein our sales engineers use their expertise in chemistry to steadily support our customers, from both product distribution and technique. We have always valued open communication with our customers and have carefully fostered their trust. With this, we are able to accurately determine the needs of our customers each time and then provide fast and beneficial technical suggestions to them.


The 31st IFSCC Congress- Presentation -

IFSCC presentation history

14th IFSCC Congress Barcelona 1986

Evaluation method of the degree of hair damage (I)
“The one-point test” by the width of 1 mm, which is applicable to a hair pick at several points

15th and 16th IFSCC conference Taipei 2001

Encapsulation of hydrophobic components with siliconized polypeptides and properties of those capsules

22nd IFSCC Congress Edinburgh 2002

The characteristic of microcapsule by entirely new wall material “silicone resin polypeptide” and the application

17th IFSCC conference Seoul 2003

The feature of microcapsule involving ultraviolet rays absorbent

23rd IFSCC Congress Orlando 2004

Evaluation of a multi-functional hybrid polymer based on a novel technology; as emulsifier, lastarizer, smoother, texture enhancer and moisturizer

23rd IFSCC Congress Orlando 2004

A high performance hair treatment to enhance moisture, hair sense, adhesion and anti-discoloring based on a novel hybrid polymer

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24th IFSCC Congress Osaka Japan 2006

Application to cosmetics, of microcapsule which encapsuled UV absorbers

24th IFSCC Congress Osaka Japan 2006

Effect to hair conditioner, of an uniquely developed hybrid polymer consisted of hydrolyzed wheat protein, silicone and alkyl chain

24th IFSCC Congress Osaka Japan 2006

Development and application of a new moisturizer, N-glycerylarginine HCl salt

24th IFSCC Congress Osaka Japan 2006

Characterization of a hydrolyzed pea protein, similar to hydrolyzed keratin

19th IFSCC conference Amsterdam 2007

The properties and application of a novel W/O emulsifier with high emulsifying ability and stability for silicone oil

25th IFSCC Congress Barcelona 2008

Application of Peptide/Silicon hybrid active interfacial modifier(AIM) to encapsulate glycerin into lipstick formulation

20th IFSCC Conference Melbourne 2009

Peptide-silicone based microcapsule suitable to suncare products

21st IFSCC Conference Bangkok 2011

Development of a multi-functional hybrid-polymer made from peptide/silicone and its applications

21st IFSCC Conference Bangkok 2011

A peptide derivative developed with focusing on hair-surface structure and its application to silicone free conditioners

27th IFSCC Congress Johannesburg 2012

Relationship between the molecular structures of glyceryl-ascorbate derivatives and their inhibitory effects on melanogenesis

22nd IFSCC Conference Rio de Janeiro 2013

Relationship between the molecular structures of alkyl glyceryl-ascorbate derivatives and their inhibitory effects on melanogenesis

23rd IFSCC Conference Zurich 2015

New benefits of a novel ascorbic acid derivative on skin homeostasis ~3-O-laurylglyceryl ascorbate~【Abstract】 To improve the disadvantages of existing water-soluble ascorbic acid (AsA) derivatives on their skin barrier function, we added a laurylglyceryl group to AsA to produce 3-O-laurylglyceryl ascorbate (3LGA). Although 3LGA had less ability to scavenge reactive oxygen species (ROS), it elicited a superior reduction of intracellular ROS with or without extracellular stimuli such as exposure to H2O2 or UVB. In addition, 3LGA increased ceramide synthesis associated with the stimulation of serine palmitoyl transferase (SPT) mRNA expression.

29th IFSCC Congress Orlando 2016

Oxidative stress is a trigger that induces sensitive skin: Benefit of a unique antioxidant to improve sensitive skin【Abstract】 In this study, we attempted to clarify the relationship between oxidative stress and sensitive skin development. Our results demonstrate that the dry skin models and H2O2-treated keratinocytes had up-regulated expression levels of interleukin-1α (IL-1α) and nerve growth factor (NGF). Furthermore, those factors induced the elongation of dendrites on nerve cells. 3-O-Laurylglyceryl ascorbate (VC-3LG) restored the expression levels of IL-1α and NGF. Therefore, we conclude that VC-3LG is an effective material to improve sensitive skin.

24th IFSCC Conference Seoul 2017

Interference with intracellular melanosome transport to improve pigmented spots; involvement of the autophagy system【Abstract】 In this study, we investigated the fate of MSs that accumulate in B16 melanoma cells due to the k nock down of MyosinVa (M KD). Our results indicate that the disruption of MS transport causes the degradation of MSs by autophagy. 3-O-glyceryl-2-O-hexyl ascorbate (VC HG), which is an inhibitor of MS transport, suppressed melanin production through the activation of autophagy. Therefore, we consider the disruption of MS transport a s an effective approach to maintain skin appearance and beauty.

Advantages of a novel ascorbic acid derivative “bis-glyceryl ascorbate” in skin moisturizing and stability of formulation【Abstract】 To improve the stability of ascorbic acid (AsA) in cosmetic formulations, we developed a novel AsA derivative, bis-glyceryl ascorbate (VC-DG), which introduces 2 glycerol groups into AsA. In this study, we evaluated the skin moisturizing effects of VC-DG focusing on the cornified cell envelope (CE) to develop its unique biological activities. The results show that VC-DG reinforces CE formation by up-regulating the expression of CE-related substances, which in turn improves stratum corneum hydration. Therefore, we conclude that VC-DG is an effective AsA derivative focusing on skin moisturizing.

30th IFSCC Congress Munich 2018

3-O-glyceryl ascorbate suppresses the loss of elastic fibers initiated by UVA, blue light and near-infrared light【Abstract】 In this study, we examined the impact of UVA, BL and NIR on the reconstruction of elastic fibers, and evaluated the effects of 3-O-glyceryl ascorbate (VC-3G) to restore its alterations. Exposure to each light increases intracellular ROS, thereby depleting elastic fibers. VC-3G suppressed the elevation of intracellular ROS and restored the mRNA expression levels of genes responded by each light. Therefore, we conclude that VC-3G is an effective derivative of ascorbic acid that prevents elastic fibers depleted by exposure to solar light.

25th IFSCC Conference Milan 2019

3-O-laurylglyceryl ascorbate, an ascorbic acid derivative, strengths epidermal barrier function【Abstract】 To exert barrier function effectively, it is necessary to produce not only ceramide but also cholesterol and free fatty acids. In this study, we investigated the potential of 3-O-laurylglyceryl ascorbate (VC-3LG) to strengthen the epidermal barrier function, focusing on the synthesis of intercellular lipids, cholesterol and free fatty acids. Our results demonstrated that VC-3LG increased cholesterol, fatty acids synthesis and upregulated mRNAs of lipid transportation into lamellar body. Therefore, we conclude that VC-3LG is an effective ascorbic acid derivative that reinforces the epidermal barrier function by increasing the synthesis of intercellular lipids.

Moreover, we have presented at various international conference, ASCS: Asian Societies of Cosmetic Scientists, CESIO: the European Committee of Organic Surfactants and their Intermediates and so on.

At the end

It’s an honor for us to present the result of research at IFSCC, such as historical international conference. We will continue to research and develop toward “unknown-possibility” which exists in global beauty and health trend in order to present a new finding at IFSCC.
In rapid changing world situation, SEIWA KASEI CO., LTD. never stop developing original unique products so as to realize people wish “Be beautiful and healthy.”