The 31st IFSCC
Congress
2020 Yokohama
About
SEIWA KASEI
Research and development-oriented chemical manufacturing company that develops cosmetic raw materials
With development, evaluation and surveying being the cornerstones of our research and development system, SEIWA KASEI CO., LTD. is a research and development - oriented company taking on the challenge of developing new materials based on the solid evidence of our original research technologies.
Since its establishment in 1958, we have presented the results of its research at large-scale conferences of cosmetics and personal care scientific societies. Also we actively carry out patent applications for our products to let the public know and understand the innovative research technologies borne out of SEIWA KASEI’s development of original materials.
Number of Japanese patent applications: 304 applications
Number of International patent applications: 78 applications
Established its status as innovative developer in cosmetic industry with over 100 original ingredients
SEIWA KASEI CO., LTD. which is widely known as a well-established manufacturer, began in the 1960s with its development of hydrolyzed collagen (collagen peptide) as raw material for cosmetics. After that, we have since evolved and expanded at a rapid rate alongside the development of applied technologies.
We have been aiming to develop raw materials with biochemical functions in new research fields and have started to develop amino acid derivatives and vitamin C derivatives since the early 2000s. Our company has since then created unique and functional raw materials. SEIWA KASEI CO., LTD. is never satisfied with the existing state and will constantly keep developing new raw materials for cosmetics that are high quality, multifunctional and original.
Delivers “SEIWA-quality” all over the world
We expands sales network in corporation with local distributor and export our products to the world. With the delivery of high-quality service as our watchword, SEIWA SUPPLY CO., LTD. has established a system wherein our sales engineers use their expertise in chemistry to steadily support our customers, from both product distribution and technique. We have always valued open communication with our customers and have carefully fostered their trust. With this, we are able to accurately determine the needs of our customers each time and then provide fast and beneficial technical suggestions to them.
The 31st IFSCC Congress- Presentation -
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Part 1
Establishment of a skin inflammation model induced by exposure to multiple environmental stimuli and the anti-inflammatory effect of 3-O-laurylglyceryl ascorbate
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Part 2
3-O-Glyceryl 2-O-hexyl ascorbic acid prevents the initiation and maintenance of skin pigmentation triggered by advanced glycation end-products in keratinocytes
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Part 3
Re-hydrophobicization of hair with the botanical hair conditioning ingredient that mimics the surface structure of hair
Title
Establishment of a skin inflammation model induced by exposure to multiple environmental stimuli and the anti-inflammatory effect of 3-O-laurylglyceryl ascorbate
Category
Environmental factors ／ Poster-122
Abstract
In this study, in order to reproduce the inflammatory situation in skin , we designed an in vitro inflammation model using reconstructed human epidermal equivalents (RHEEs) exposed to diesel exhaust particles (DPs) and UVB. In that model, intracellular ROS levels and inflammatory substances were synergistically increased by treatment with DPs and UVB. We evaluated the anti-inflammatory effects of 3-O-laurylglyceryl ascorbate (VC-3LG), which is an ascorbic acid derivative, using the RHEE inflammation model. VC-3LG inhibited the promotion of intracellular ROS levels and the production of inflammatory. Furthermore, the long-term application of VC-3LG significantly decreased the erythema index in a human volunteer test. Therefore, we conclude that VC-3LG is a unique material that protect cells against multiple external stimuli.
Related product
Amitose 3LGA
Title
3-O-Glyceryl 2-O-hexyl ascorbic acid prevents the initiation and maintenance of skin pigmentation triggered by advanced glycation end-products in keratinocytes
Category
Melanogenesis ／ Poster₋28
Abstract
In this study, to clarify the mechanism of pigmentation induced by AGEs, we investigated the influence of AGEs synthesized in keratinocytes focusing on their effect on the process of pigmentation. The results show that the intracellular accumulation of AGEs induces an enhanced melanosome (MS) uptake into keratinocytes and the dysfunction of cathepsins, which are proteases involved in degrading MSs. 3-O-glyceryl-2-O-hexyl ascorbate (VC-HG), which is an ascorbic acid derivative, restored the excess uptake of MSs and the dysfunction of cathepsins in keratinocytes associated with the suppression of AGE formation. Therefore, we propose that VC-HG is an attractive material to prevent the accumulation of MSs in the epidermis through the suppression of AGE formation.
Related product
Amitose HGA
Title
Re-hydrophobicization of hair with the botanical hair conditioning ingredient that mimics the surface structure of hair
Category
Hair biology ／ Poster₋100
Abstract
We have developed a botanical pseudo cuticle component (BPCu) that imitates hair surface structure as an ingredient to repair 18-methyleicosanoic acid (18-MEA) present on the surface of hair that is released due to daily damage. The effect of this component on the hair surface was evaluated. BPCu is sufficient adsorption was confirmed even in a shampoo formulation containing a large amount of surfactant, and the effect of making the hydrophilized hair hydrophobic was confirmed. We also performed a sensory evaluation using a shampoo containing BPCu, and confirmed that the sensory characteristics were improved not only after drying but also when the hair got wet during washing. For consumers who refrain from synthetic polymers such as silicones, this component composed of plant-derived components is considered to be a useful alternative that can be used as a substitute.
Related product
Vegetamide 18MEA-NJ
IFSCC presentation history
14th IFSCC Congress Barcelona 1986
Evaluation method of the degree of hair damage (I)
“The one-point test” by the width of 1 mm, which is applicable to a hair pick at several points
15th and 16th IFSCC conference Taipei 2001
Encapsulation of hydrophobic components with siliconized polypeptides and properties of those capsules
22nd IFSCC Congress Edinburgh 2002
The characteristic of microcapsule by entirely new wall material “silicone resin polypeptide” and the application
17th IFSCC conference Seoul 2003
The feature of microcapsule involving ultraviolet rays absorbent
23rd IFSCC Congress Orlando 2004
Evaluation of a multi-functional hybrid polymer based on a novel technology; as emulsifier, lastarizer, smoother, texture enhancer and moisturizer
23rd IFSCC Congress Orlando 2004
A high performance hair treatment to enhance moisture, hair sense, adhesion and anti-discoloring based on a novel hybrid polymer
24th IFSCC Congress Osaka Japan 2006
Application to cosmetics, of microcapsule which encapsuled UV absorbers
24th IFSCC Congress Osaka Japan 2006
Effect to hair conditioner, of an uniquely developed hybrid polymer consisted of hydrolyzed wheat protein, silicone and alkyl chain
24th IFSCC Congress Osaka Japan 2006
Development and application of a new moisturizer, N-glycerylarginine HCl salt
24th IFSCC Congress Osaka Japan 2006
Characterization of a hydrolyzed pea protein, similar to hydrolyzed keratin
19th IFSCC conference Amsterdam 2007
The properties and application of a novel W/O emulsifier with high emulsifying ability and stability for silicone oil
25th IFSCC Congress Barcelona 2008
Application of Peptide/Silicon hybrid active interfacial modifier(AIM) to encapsulate glycerin into lipstick formulation
20th IFSCC Conference Melbourne 2009
Peptide-silicone based microcapsule suitable to suncare products
21st IFSCC Conference Bangkok 2011
Development of a multi-functional hybrid-polymer made from peptide/silicone and its applications
21st IFSCC Conference Bangkok 2011
A peptide derivative developed with focusing on hair-surface structure and its application to silicone free conditioners
27th IFSCC Congress Johannesburg 2012
Relationship between the molecular structures of glyceryl-ascorbate derivatives and their inhibitory effects on melanogenesis
22nd IFSCC Conference Rio de Janeiro 2013
Relationship between the molecular structures of alkyl glyceryl-ascorbate derivatives and their inhibitory effects on melanogenesis
23rd IFSCC Conference Zurich 2015
New benefits of a novel ascorbic acid derivative on skin homeostasis ~3-O-laurylglyceryl ascorbate~【Abstract】 To improve the disadvantages of existing water-soluble ascorbic acid (AsA) derivatives on their skin barrier function, we added a laurylglyceryl group to AsA to produce 3-O-laurylglyceryl ascorbate (3LGA). Although 3LGA had less ability to scavenge reactive oxygen species (ROS), it elicited a superior reduction of intracellular ROS with or without extracellular stimuli such as exposure to H2O2 or UVB. In addition, 3LGA increased ceramide synthesis associated with the stimulation of serine palmitoyl transferase (SPT) mRNA expression.
29th IFSCC Congress Orlando 2016
Oxidative stress is a trigger that induces sensitive skin: Benefit of a unique antioxidant to improve sensitive skin【Abstract】 In this study, we attempted to clarify the relationship between oxidative stress and sensitive skin development. Our results demonstrate that the dry skin models and H2O2-treated keratinocytes had up-regulated expression levels of interleukin-1α (IL-1α) and nerve growth factor (NGF). Furthermore, those factors induced the elongation of dendrites on nerve cells. 3-O-Laurylglyceryl ascorbate (VC-3LG) restored the expression levels of IL-1α and NGF. Therefore, we conclude that VC-3LG is an effective material to improve sensitive skin.
24th IFSCC Conference Seoul 2017
Interference with intracellular melanosome transport to improve pigmented spots; involvement of the autophagy system【Abstract】 In this study, we investigated the fate of MSs that accumulate in B16 melanoma cells due to the k nock down of MyosinVa (M KD). Our results indicate that the disruption of MS transport causes the degradation of MSs by autophagy. 3-O-glyceryl-2-O-hexyl ascorbate (VC HG), which is an inhibitor of MS transport, suppressed melanin production through the activation of autophagy. Therefore, we consider the disruption of MS transport a s an effective approach to maintain skin appearance and beauty.
Advantages of a novel ascorbic acid derivative “bis-glyceryl ascorbate” in skin moisturizing and stability of formulation【Abstract】 To improve the stability of ascorbic acid (AsA) in cosmetic formulations, we developed a novel AsA derivative, bis-glyceryl ascorbate (VC-DG), which introduces 2 glycerol groups into AsA. In this study, we evaluated the skin moisturizing effects of VC-DG focusing on the cornified cell envelope (CE) to develop its unique biological activities. The results show that VC-DG reinforces CE formation by up-regulating the expression of CE-related substances, which in turn improves stratum corneum hydration. Therefore, we conclude that VC-DG is an effective AsA derivative focusing on skin moisturizing.
30th IFSCC Congress Munich 2018
3-O-glyceryl ascorbate suppresses the loss of elastic fibers initiated by UVA, blue light and near-infrared light【Abstract】 In this study, we examined the impact of UVA, BL and NIR on the reconstruction of elastic fibers, and evaluated the effects of 3-O-glyceryl ascorbate (VC-3G) to restore its alterations. Exposure to each light increases intracellular ROS, thereby depleting elastic fibers. VC-3G suppressed the elevation of intracellular ROS and restored the mRNA expression levels of genes responded by each light. Therefore, we conclude that VC-3G is an effective derivative of ascorbic acid that prevents elastic fibers depleted by exposure to solar light.
25th IFSCC Conference Milan 2019
3-O-laurylglyceryl ascorbate, an ascorbic acid derivative, strengths epidermal barrier function【Abstract】 To exert barrier function effectively, it is necessary to produce not only ceramide but also cholesterol and free fatty acids. In this study, we investigated the potential of 3-O-laurylglyceryl ascorbate (VC-3LG) to strengthen the epidermal barrier function, focusing on the synthesis of intercellular lipids, cholesterol and free fatty acids. Our results demonstrated that VC-3LG increased cholesterol, fatty acids synthesis and upregulated mRNAs of lipid transportation into lamellar body. Therefore, we conclude that VC-3LG is an effective ascorbic acid derivative that reinforces the epidermal barrier function by increasing the synthesis of intercellular lipids.
Moreover, we have presented at various international conference, ASCS: Asian Societies of Cosmetic Scientists, CESIO: the European Committee of Organic Surfactants and their Intermediates and so on.
At the end
It’s an honor for us to present the result of research at IFSCC, such as historical international conference. We will continue to research and develop toward “unknown-possibility” which exists in global beauty and health trend in order to present a new finding at IFSCC.
In rapid changing world situation, SEIWA KASEI CO., LTD. never stop developing original unique products so as to realize people wish “Be beautiful and healthy.”